Problem
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My USB devices such as pendrive and external hard disk does not respond after I plug it to my PC. The auto-run does not appear and when I go to My Computer I did not see my devices/drive there. But then I can see the Safely Add and Remove Devices is there at System Tray.
Solution
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Click Start.
Click Run. (Or you can just hold Window+R key)
Now, type diskmgmt.msc
Then Right Click the partition whose Drive Letter you want to change.
Select Change Drive Letter and select your desired path to use for your devices (Any letter but not C and path that you had been using)